Hello and Happy 2013. It’s been a while since I last posted. This is mainly because I haven’t had anything to post. Well…
The news from most recent PCR is that I have lost my molecular response. The b3a2 fusion gene transcript found in chronic myelogenous leukemia was detected. What does this mean? It means that the CML gene is replicating again. Put in English, I am technically no longer in remission.
Before you start freaking out, the level of this transcript present at diagnosis was 52%. The amount detected on this current blood draw is seven tenths of one percent (0.7%).
The bigger question is, why? I have been taking Sprycel for over a year now. I’ve been in a major molecular response for over a year. My doctor has drawn additional blood to check for gene mutations, but for now I think the reason for the change is a Drug-Drug interaction. Possibly, a 10 cent ant-acid pill brought down a $275 cancer drug. I have some acid reflux and take Tums for it. I believe I have been taking this too close to my Sprycel dose.
I have Tums at work, at home and in the car. I take around 20 tablets a day. I’ve used this opportunity to ask myself why I am taking so much Tums?!?! Well, I’ve taken the advice of two of my doctors and have cut out the diet soda. And, so far (it’s been a week) I can say the reflux seems to be much better. Diet Dr. Pepper, I miss will (yes, the photo is of Diet Coke, I couldn’t find one of Dr. Pepper).
I will continue to take the Sprycel for now. In about three weeks we will recheck the PCR to see if the numbers are headed back down.